The fictional Hayward Sanitarium, a psychiatric facility where strange and paranormal events are commonplace, is located in New England and serves as the central point for the series exploration of the supernatural and psychological horror. Each episode often features a different patient's story, providing a new and eerie tale that contributes to the overarching mystery of the place.

Dr. Hayward, the founder of the sanitarium, is a recurring character who helps to navigate through the complex and disturbing events occurring within the institution. The stories blend psychological elements with traditional horror, making for gripping and spooky listening. As a nod to classic OTR horror shows, "Hayward Sanitarium" captures the essence of vintage radio drama with its sound design and storytelling style, making it a beloved series among modern fans of the genre.